Do Cellartis enhanced hiPS-HEP cells express phase II enzymes?
Do Cellartis enhanced hiPS-HEP cells express phase II enzymes?
Yes. In our tests, Cellartis enhanced hiPS-HEP cells showed mRNA expression of UGT1A1 and UGT2B7 at similar or higher levels than cryopreserved human primary hepatocytes. Enhanced hiPS-HEP cells displayed phase II enzyme activities, e.g., UGT and sulfotransferase activities, at similar or higher levels as in cryopreserved human primary hepatocytes cultured for 24 hours, as measured by LC/MS.
