Are there published examples of AAV2 being used for in vivo gene transfer?
Are there published examples of AAV2 being used for in vivo gene transfer?
AAV2 particles generated using the AAVpro series were successfully used for in vivo delivery of a bright fluorescent marker to cells in a very specific brain region in mouse.
Gene transfer into the mouse striatum via recombinant AAV2 particles generated using the AAVpro series.
In addition, AAV2 was used for gene delivery in the following studies (none of these examples use AAVpro products).
Brain
AAV2 used to deliver Cre to the subventricular zone
Lee N., et al. Ciliary neurotrophic factor receptor regulation of adult forebrain neurogenesis. J. Neurosci. 33, 1241–1258 (2013).
Brain
AAV2 was used for gene delivery directly to the hippocampus
Passini MA, et al. AAV vector-mediated correction of brain pathology in a mouse model of Niemann-Pick A disease. Mol. Ther. 11, 754–762 (2005).
Liver
AAV2 carrying a gene under the control of a liver-specific promoter was intravenously administered to mice
Ziegler RJ, et al. AAV2 Vector Harboring a Liver-Restricted Promoter Facilitates Sustained Expression of Therapeutic Levels of a-Galactosidase A and the Induction of Immune Tolerance in Fabry Mice. Mol. Ther.9, 231–240 (2004).
Pancreas
AAV2 was used for gene delivery to mouse pancreas
Wang AY, et al. Comparison of adenoviral and adeno-associated viral vectors for pancreatic gene delivery in vivo. Hum Gene Ther. 15, 405–413 (2004).