Are Cellartis enhanced hiPS-HEP cells genetically engineered?
Are Cellartis enhanced hiPS-HEP cells genetically engineered?
No. In some hepatocytes genetic engineering is used to improve hepatic function. Instead, we developed a culture protocol that substantially improves functionality. Each hiPS cell line—the source of the Cellartis hepatocytes—was reprogrammed using an integrative, retroviral technique. We tested for reverse transcriptase activity in the hiPS cell lines to confirm the absence of replication-competent retroviruses. We also confirmed that the factors used for reprogramming were silenced in the hiPS cell lines.