What is the source of Cellartis enhanced hiPS-HEP cells?
What is the source of Cellartis enhanced hiPS-HEP cells?
Cellartis enhanced hiPS-HEP cells are differentiated from human induced pluripotent stem (hiPS) cell lines ChiPSC12, ChiPSC18, and ChiPSC22. These lines were created by reprogramming human dermal fibroblasts with defective polycistronic retrovirus technology, which includes a retroviral vector containing Oct4, Sox2, Klf4, and c-Myc (pRV-OCT4-SOX2-KLF4-MYC; the vector map is proprietary). Reverse transcriptase activity testing shows that the hiPS cell lines do not contain replication-competent retroviruses. In addition, the viral reprogramming genes are silenced.