How do the hepatocytes derived with this system compare to human primary hepatocytes?
How do the hepatocytes derived with this system compare to human primary hepatocytes?
One of the major differences is that the functionality of primary hepatocytes declines rapidly in culture due to a dedifferentiation process, whereas hepatocytes derived with our system can be kept in culture for several weeks with maintained functionality. In addition, different batches of human primary hepatocytes show large donor variations due to the pronounced metabolic diversity in the human population, which causes problems for researchers when one is forced to switch to new batches between experiments or studies. Similar to human primary hepatocytes, hepatocytes derived with this system demonstrate many key hepatocyte functions such as albumin secretion and LDL uptake. See our tech note for more information.