What are some example applications of pooled whole-genome sgRNA library screens?
What are some example applications of pooled whole-genome sgRNA library screens?
Some examples where sgRNA pooled screens have been applied include investigations in:
-Mechanisms associated with ALS and Parkinson's Disease (ALS citation: https://www.ncbi.nlm.nih.gov/pubmed/29507424; Parkinson's citation: https://www.ncbi.nlm.nih.gov/pubmed/29269392)
-Oncology—looking at growth and metastasis (citation: https://www.ncbi.nlm.nih.gov/pubmed/25748654)
-Responses in immune therapy (citation: https://www.ncbi.nlm.nih.gov/pubmed/28783722)
-Mechanisms of viral infection (citation: https://www.ncbi.nlm.nih.gov/pubmed/27383988)