Can the DNA SMART Poly(dA) Primer  anneal to internal /A -rich sequences in the genomic DNA?

Can the DNA SMART Poly(dA) Primer  anneal to internal /A -rich sequences in the genomic DNA?

DNA SMART Poly(dA) Primer  can anneal to the T/A -rich sequences in the genomic DNA.  The level of T/A noise in the final DNA SMART™ ChIP library may vary between different target DNAs. To remove the background noise consider a software tool described by Zhao and Zheng BMC Bioinformatics (2018) 19:544 - SMARTcleaner: identify and clean off-target signals in SMART ChIP-seq analysis

ChIP-seq and small RNA-seq products

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